Количество страниц: 4 с.
Особенности иммунного и метаболического профиля вегетативной дисфункции, сопряженные с полиморфизмом генов-кандидатов / О. В. Долгих, Н. В. Зайцева, Н. А. Никоношина // Якутский медицинский журнал. — 2021. — N 1 (73). — С. 54-57
DOI: 10.25789/YMJ.2021.73.15
Количество страниц: 2 с.
Оценка влияния курения на нарушения бронхиальной проходимости у геронтов г. Якутска / С. В. Обутова, Н. И. Логвиненко, З. П. Горохова, Л. В. Щербакова // Якутский медицинский журнал. – 2011. – N 3 (35). – С. 56-57.
Количество страниц: 4 с.
Adaptive physical culture forms a conscious attitude to one’s strength, the ability to overcome not only physical, but also psychological barriers that prevent one from leading a fulfilling life. In article the authors defined adaptive physical culture not only as a method of using physical education for people with health problems, but also as a research task in the general program for studying neurodegenerative diseases at the Yakut Science Centre of Complex Medical Problems
Адаптивная физическая культура как интегративная наука / А. М. Кононов, С. К. Кононова, Т. К. Давыдова [и другие] // Якутский медицинский журнал. — 2020. — N 1 (69). — С. 99-102. – DOI: 10.25789/YMJ.2020.69.24.
DOI: 10.25789/YMJ.2020.69.24
Количество страниц: 4 с.
Each ecological region has individual characteristics of metabolism particularly because of the indefinite landscape zone that can be inhabited by people of different ethnic and racial origin. The environmental factor of nutrition has a great influence on the metabolism characteristics. What macro- and micronutrients are consumed with food becomes a prognostic sign of the development of alimentary-dependent deviations that directly affect functional parameters of the body systems. The diet of 17-21 year old male indigenous residents of Magadan region (n = 38) and Chukotka Autonomous District (n = 52) has been analyzed. All the examinees were full-time students having similar living conditions. The ASPON-Nutrition program (Russia) was used to evaluate the young subjects' nutritional profiles by analyzing their daily diets. The studied parameters were proteins, fats, carbohydrates, fiber, vitamins, and macro- and microelements. In addition, the energy value of the daily diet was assessed in kcal / day. Larger deviations from the current normative values of the body physiological needs in macro- and micronutrients have been found. The nutritional imbalance characterized by insufficient intake of proteins, fats, essential trace elements, and vitamins against the background of reduced energy value of daily calorie content has been shown. The revealed deficiency is much more typical at young men living in the city of Magadan. In general, the multilateral imbalance established in the diet of young indigenes indicates a violation of the basic principles of healthy eating (satisfying energy needs, balancing proteins, fats, carbohydrates) and can be associated with avoiding the traditional type of the diet by the indigenous population and turning to the classical Caucasian one which does not provide all the needs of the body of this ethnicity
Аверьянова, И. В. Анализ макро-и микронутриентного профиля рациона питания юношей-аборигенов Северо-Востока России / И. В. Аверьянова, С. И. Вдовенко // Якутский медицинский журнал. — 2020. — N 4 (72). — С. 102-105
DOI: 10.25789/YMJ.2020.72.25
Количество страниц: 10 с.
Non-coding RNAs (miRNAs and long non-coding RNAs (lncRNA)) play an important role in many biological processes, and dysregulation can lead to various diseases, including colorectal cancer (CRC). The aim of the study was to analyze the differential expression of miRNAs in the tumor and normal tissues of patients with CRC, as well as the identification of potential lncRNA targets and target genes using methods of machine learning. Analysis of miRNA expression was performed by multiple parallel sequencing on a MiSeq instrument. For bioinformation analysis, DESeq2, TarPmiR, ORA (Over-Representation Analysis) and FMD (Functional module detection) algorithms were used. Sequencing revealed 6 differentially expressed microRNAs (hsa-miR-143-3p, hsa-miR-26a-5p, hsa-miR-25-3p, hsa-miR-92a-3p, hsa-miR-21-5p, hsa -let-7i-5p) in the tumor tissue of the colon is relatively normal. For these microRNAs, 97 target genes and 23 potentially interacting long non-coding RNAs were identified. Together they form a network of competitively expressed RNA characteristic of CRC, which is involved in the implementation of signaling cascades such as regulation of cell adhesion, activation of the immune response, regulation of the cellular response to hormones and stress, Wnt signaling pathway and cell migration regulation, regulation of proliferation and cell cycle, regulation interaction with viral agents, regulation of apoptosis and response to hypoxia. The data obtained expand the understanding of the mechanisms of gene expression regulation in CRC and can become the basis for a panel of tumor markers
Новикова, И. А. Дифференциальная экспрессия микро РНК в опухолевыхи нормальных тканях толстый кишки / И. А. Новикова, Н. Н. Тимошкина, Д. С. Кутилин // Якутский медицинский журнал. — 2020. — N 4 (72). — С. 74-82
DOI: 10.25789/YMJ.2020.72.19
Количество страниц: 6 с.
- Прикладные науки. Медицина. Ветеринария. Техника. Сельское хозяйство > Медицина > Гигиена. Санитария,
- Прикладные науки. Медицина. Ветеринария. Техника. Сельское хозяйство > Медицина > Анатомия. Физиология,
- НАУКА ЯКУТИИ > ПРИКЛАДНЫЕ НАУКИ. МЕДИЦИНА. ТЕХНИКА. СЕЛЬСКОЕ ХОЗЯЙСТВО > Медицина > Анатомия. Физиология,
- НАУКА ЯКУТИИ > ПРИКЛАДНЫЕ НАУКИ. МЕДИЦИНА. ТЕХНИКА. СЕЛЬСКОЕ ХОЗЯЙСТВО > Медицина > Гигиена. Санитария.
The limits and correlation of apoptosis and necrosis of neutrophil granulocytes in venous peripheral blood in apparently healthy people were studied. It was found that w contehen increasing the content of necrotic neutrophils AnV+/PI+, the concentration of apoptotic cells AnV+/PI-increases statistically to a large extent associated with the reduction of circulating neutrophils, monocytes, and t-helper cells. Thus, activation of neutrophil loss by necrosis can become a pathogenetic mechanism of cell membrane damage (nuclear, lysosomal, or cellular), as well as the formation of T-helper immunodeficiency
Соотношение уровня некроза и апоптоза нейтрофилов периферической крови у практически здоровых северян / О. А. Ставинская, Л. К. Добродеева, С. Н. Балашова, В. П. Патракеева // Якутский медицинский журнал. — 2020. — N 4 (72). — С. 23-27
DOI: 10.25789/YMJ.2020.72.06
Количество страниц: 4 с.
Article is intended to acquaint the reader with experience in applying the methods of the human and natural sciences for the reconstruction of the diet of the ancient Yakuts. Ethnographic texts, archaeological material, analysis of the stable carbon isotopes δ13С and nitrogen δ15N on the bone collagen of humans, animals and fish were used. The advantages and disadvantages of using this analysis are noted. Detection of toxic substances in the hair of the deceased was made
Междисциплинарный подход в изучении питания якутов с XVII по XIX в. / Л. Г. Романова, Н. В. Покатилова, В. Бальтер, Э. Крюбези // Якутский медицинский журнал. — 2020. — N 1 (69). — С. 73-76
DOI: 10.25789/YMJ.2020.69.17
Количество страниц: 6 с.
The article analyzes the respiratory function indicators in two ethnically different groups (Yakuts and Russians) of the Republic Sakha (Yakutia) of the same age and sex. It shows that in the Yakuts, compared to Russians, some reserve respiratory system indicators are reduced. The results of a study of respiratory function in smokers show a significant respiratory obstruction caused by tobacco smoke. The degree of respiratory obstruction in smokers increases in direct proportion to the length of time they smoke. Against the background of smoking increases hypoxia, blood oxygenation and oxygen transport to tissues. In smokers, the rate of lipid peroxidation and the condition of antioxidant protection of the body depend on the length of time they smoke
Физиолого-биохимические аспекты табакокурения в условиях Якутии / Г. Е. Миронова, Л. Д. Олесова, Е. И.Семенова [и другие] // Якутский медицинский журнал. — 2020. — N 1 (69). — С. 58-62
DOI: 10.25789/YMJ.2020.69.14
Количество страниц: 4 с.
- Прикладные науки. Медицина. Ветеринария. Техника. Сельское хозяйство > Медицина > Гигиена. Санитария,
- Прикладные науки. Медицина. Ветеринария. Техника. Сельское хозяйство > Медицина > Гинекология. Женские болезни. Акушерство,
- НАУКА ЯКУТИИ > ПРИКЛАДНЫЕ НАУКИ. МЕДИЦИНА. ТЕХНИКА. СЕЛЬСКОЕ ХОЗЯЙСТВО > Медицина > Гинекология. Женские болезни. Акушерство,
- НАУКА ЯКУТИИ > ПРИКЛАДНЫЕ НАУКИ. МЕДИЦИНА. ТЕХНИКА. СЕЛЬСКОЕ ХОЗЯЙСТВО > Медицина > Гигиена. Санитария.
The results of the analysis of statistical connection between annual (from 2007 to 2018) values of age- standardized death rates (ASD) from cervical cancer (CC) and demographic indicators - number and density of population, location of population on the "city-rural" principle, among the population of the republics - Altai, Buryatia, Tyva, Khakassia and Sakha (Yakutia) are presented. Positive correlation between the ASDs due to the CC and the indicator of the share of rural settlements in the republics has been revealed (correlation coefficient Spearman (r) = 0.7, p≤0.05). With the other demographic indicators selected for the study, the correlation has not reached the required strength and reliability (r0.05)
Сопряженность смертности от рака шейки матки с численностью и размещением населения в республиках РФ, расположенных в Сибири, в период с 2007 по 2018 г. / И. В. Кононова, М. П. Кириллина, С. И. Софронова [и другие] // Якутский медицинский журнал. — 2020. — N 1 (69). — С. 46-49
DOI: 10.25789/YMJ.2020.69.11
Количество страниц: 10 с.
Организация питания детей и подростков на региональном уровне / Лебедева У. М., //Вопросы питания. - 2018.-Т. 83, N 6-С. 48-56